Heat shock factor 1 mediates the longevity conferred by inhibition of TOR and insulin/IGF-1 signaling pathways in C. elegans

Target of rapamycin (TOR) signaling is an evolutionarily well-conserved pathway that regulates various physiologic processes, including aging and metabolism. One of the key downstream components of TOR signaling is ribosomal protein S6 kinase (S6K) whose inhibition extends the lifespan of yeast, Caenorhabditis elegans, Drosophila, and mice. Here, we demonstrate that the activation of heat shock factor 1 (HSF-1), a crucial longevity transcription factor known to act downstream of the insulin/IGF-1 signaling (IIS) pathway, mediates the prolonged lifespan conferred by mutations in C.elegans S6K (rsks-1). We found that hsf-1 is required for the longevity caused by down-regulation of components in TOR signaling pathways, including TOR and S6K. The induction of a small heat-shock protein hsp-16, a transcriptional target of HSF-1, mediates the long lifespan of rsks-1 mutants. Moreover, we show that synergistic activation of HSF-1 is required for the further enhanced longevity caused by simultaneous down-regulation of TOR and IIS pathways. Our findings suggest that HSF-1 acts as an essential longevity factor that intersects both IIS and TOR signaling pathways.X1144sciescopu

Lane Endpoint Detection and Position Accuracy Evaluation for Sensor Fusion-Based Vehicle Localization on Highways

Landmark-based vehicle localization is a key component of both autonomous driving and advanced driver assistance systems (ADAS). Previously used landmarks in highways such as lane markings lack information on longitudinal positions. To address this problem, lane endpoints can be used as landmarks. This paper proposes two essential components when using lane endpoints as landmarks: lane endpoint detection and its accuracy evaluation. First, it proposes a method to efficiently detect lane endpoints using a monocular forward-looking camera, which is the most widely installed perception sensor. Lane endpoints are detected with a small amount of computation based on the following steps: lane detection, lane endpoint candidate generation, and lane endpoint candidate verification. Second, it proposes a method to reliably measure the position accuracy of the lane endpoints detected from images taken while the camera is moving at high speed. A camera is installed with a mobile mapping system (MMS) in a vehicle, and the position accuracy of the lane endpoints detected by the camera is measured by comparing their positions with ground truths obtained by the MMS. In the experiment, the proposed methods were evaluated and compared with previous methods based on a dataset acquired while driving on 80 km of highway in both daytime and nighttime. Document type: Articl

Effects of electromagnetic fluctuations in plasmas on solar neutrino fluxes

We explore the effects of electromagnetic (EM) fluctuations in plasmas on solar neutrino fluxes exploiting the fluctuation-dissipation theorem. We find that the EM spectrum in the solar core is enhanced by the EM fluctuations due to the high density of the Sun, which increases the radiation energy density and pressure. By the EM fluctuations involving the modified radiation formula, the central temperature decreases when the central pressure of the Sun is fixed. With a help of the empirical relation between central temperature and neutrino fluxes deduced from the numerical solar models, we present the change in each of the solar neutrino fluxes by the EM fluctuations. We also discuss the enhanced radiation pressure and energy density by the EM fluctuations for other astronomical objects

Methodology to Predict Random Telegraph Noise Induced Threshold Voltage Shift Using Machine Learning

We suggest the methodology to predict the distribution of threshold voltage (V-t) shift caused by random telegraph noise (RTN). Poly-silicon channels were randomized with a single trap and the neural network was modeled to predict RTN trap-induced Vt fluctuation in 3D NAND Flash Memory. 3D Technology Computer-Aided Design (TCAD) simulations were performed in a unit cell to calculate the Vt shift in a 3D vertical channel. Finally, we extract the distribution of Vt fluctuation using machine learning.N

Reinvestigating the Gamow Factor of Reactions on Light Nuclei

We present a modified Gamow factor by reinvestigating the conventional assumptions used in its derivation. The conventional Gamow factor, factorized from the total cross section, effectively describes the penetration probabilities (PPs) in low-energy nuclear reactions under the assumption of particle energies significantly lower than the Coulomb barrier. However, we find that the assumption is invalid for light nuclei, resulting in PPs that depend on the nuclear potential depth for such nuclei. By adopting a potential depth fitted to experimental fusion cross sections, we demonstrate that PPs for light nuclei (D+D, D+T, D+ ^3 He, p+D, p+ ^6 Li, and p+ ^7 Li) become higher than those predicted by the conventional form near the Coulomb barrier. This reduces the Gamow peak energy by a factor of 5.3 maximally compared to the conventional form. Furthermore, we show that the enhancement factor due to the Debye screening effects in the solar core can be reduced by approximately 5%–10% due to the modified PP. Our findings hold implications for evaluating the available energy region in low-energy reaction experiments based on the Gamow peak energy region and for understanding electron screening effects in typical astrophysical environments

Dynamical Screening Effects on Big Bang Nucleosynthesis

A moving ion in plasma creates a deformed electric potential depending on the ion velocity, which leads to the distinct screening effect compared to the standard static Salpeter formula. In this paper, adopting the test charge method, we explore the dynamical screening effects on big bang nucleosynthesis (BBN). We find that the high temperature in the early universe causes the ion velocity to be faster than the solar condition so that the electric potential is effectively polarized. However, the low density of background plasma components significantly suppresses the dynamical screening effects on thermonuclear reaction rates during the BBN epoch. We compare our results with several thermonuclear reaction rates for solar fusion considering the dynamical screening effects. Also, we discuss the additional plasma properties in other astrophysical sites for the possible expansion from the present calculation in the future

Advance Directives and Factors Associated with the Completion in Patients with Heart Failure

Advance directive (AD) has been underutilized among patients with heart failure (HF). This study was performed to explore the ADs and examine factors associated with the completion of an AD survey in patients with HF. In a descriptive, correlational study, data on end-of-life values, treatment directives, and proxy (Korean-Advance Directive (K-AD) questionnaire) and factors associated with K-AD completion were collected among HF patients during outpatient visits. Of 67 patients (age, 67 years; male, 61.2%), 52.2% completed all or part of the K-AD. Among values, comfortable death was the most preferred (n = 15) followed by avoiding family burden (n = 6). In those completers, preferences for hospice care, cardiopulmonary resuscitation, ventilation support, and hemodialysis were 68.6%, 42.9%, 28.6%, and 28.6%, respectively. Female sex (odds ratio (OR) = 0.167), poorer HF prognosis (OR = 0.156), and better functional status (OR = 0.905) were associated with less likelihood of completing the AD survey. The findings suggest that in-depth AD discussion needs to be started earlier in patients with HF to facilitate completion of AD, especially in female patients. Future research should investigate if early discussion of ADs as part of advance care planning with integration into standard care of HF facilitates the documentation of ADs

Client-Centered Breastfeeding-Promotion Strategies: Q Methodology

Fewer Korean women are choosing the 6 months of exclusive breastfeeding that are recommended for obtaining its maximal benefits despite an increasing effort to promote breastfeeding. Successful breastfeeding education and counseling need to be segmentally designed on the basis of client characteristics. This study explored the perceptions of breastfeeding in pregnant and 6 month postpartum Korean women using the Q methodology, a useful research approach to examine personal perceptions, feelings, and values about a concept or phenomenon of interest and identify typologies of perspectives. The Q sample consisted of 38 statements representing the universe of viewpoints on breastfeeding. The P sample (N = 49) included women who shared their perceptions of breastfeeding and filled each grid with a statement in the Q sorting table. Data were analyzed using the PC-QUANL program. Varimax (orthogonal) rotation revealed four factors that explained 53.0% of variance: maternal privilege (Factor 1), option based on emotion (Factor 2), option if efficient (Factor 3), and option if I have sufficient problem-solving skills (Factor 4). Korean women have changed their attitudes toward breastfeeding, with all participants viewing breastfeeding as optional. Breastfeeding-promotion campaigns and education need to consider societal norms and changes in women’s beliefs and perceptions